I've heard from one gent who got Guide going on 64-bit
Vista, though he did have to use the revised setup program
at http://www.projectpluto.com/setup.htm .

It's not clear to me where you're running into trouble:
is the installer not running? Or giving you an error message?
Or does Guide install, but then not run? Or run, but give
you an error message? Or... ?

-- Bill